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b-Aroyl-a-(indole-3-yl) propionic acids (II) were prepared by the reaction of b-aroyl-acrylic acids (I) with indole. Reaction of (II) with hydrazines afforded the pyridazinomes (III) and (IV). Pyridazinone (III) reacted with POCl3, ethylbromoacetate and P2S5 to yield chloropyridasine (V). 3-O-carbethoxymethyl pyridazine (VIII) and the thione derivatives (XII) respectively. The behavior of 3-chloropyridazine towards hydrazine hydrate and acyl hydrazines was investigated. Actions of hydrazine hydrate and benzylamine on the 3-O-carbethoxymethyl pyridazine and thione (VIII) and (XII) were also investigated. Dehydration of (II) yielded the butenolide (XV). The behavior of the butenolide towards benzylamine, ammonium acetate and hydroxylamine hydrochloride was studied.read more
E. A SOLIMAN ,A Y EL-KADY ,A M EL-GENDY ,G H. TAMAM ,
- 28 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 1
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3,4-Dimethylbenzoylacrylic acid (I) reacts with hydrogen peroxide to give the corresponding epoxide (II) and with acetyl acetone under Michael conditions to give the corresponding Michael addition product 9VII) or cyclic product (VIII). The action of hydrazines, amines, hydroxylamine hydrochloride, urea and thioureas on these products has been desribed.read more
I A ATTIA ,E A SOLIMAN ,H A MOUSA ,A M HATABA ,F A EL-SHAHED ,
- 28 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 11
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(3,4-Dimethylbenzoylacryloyl)-anthranilic acid (I) was easily cyclized to the corresponding benzoxazone (IV) by the effect of Ac2O. Condensation of (IV) with hydrazine hydrate gave rise to the aminoquinazolinones (XIII). Some reactions of the above product have been investigated. read more
H A MOUSA ,E A SOLIMAN ,A M HATABA ,I A ATTIA ,F A EL-SHAHED ,A M HATABA ,H A MOUSA ,I A ATTIA ,F A EL-SHAHED ,
- 28 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 19
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Ferrocylidene ketones (1) and biferrocylidene ketones (2) were prepared by condensation of formyl ferrocene with ketones. Biferrocene (5-10) derivatives were obtained by treatment of lithioferrocene with phthalic anhydride, methyl benzoate and/or phenyl iodide respectively. The PMR and IR of these compounds are described.read more
SAYED EL NAGDY ,MONEER A.I SALEM ,AHMED Y MOHAMMED ,
- 29 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 35
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New ligands meso- and dl-bis(ethanoylacetone)-stilbenediimine meso- and dl-bis(n-propanoylactone)-stilbenediimine and their copper and nickel complexes have been prepared. The reagents and their metal complexes have been characterized using IR, UV, visible and mass spectroscopic techniques. The coloured copper and nickel complexes are studied spectrophotometrically and their DTA, TGA curves are recorded. The metal complexes particularly of dl-isomer indicate reasonable thermal stabilities, the metal complexes are eluted on OV101 on chromosorb column using GLC equipped with flame ionization detector and detection limits are found in ng range of metal ions.read more
M Y KHUHAWAR ,A G.M VASANDANI ,
- 29 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 43
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N,N-diarylethylenediimines react with Grignard reagents to give the diadducts, with phenyl isocyanate to give the succinanilide derivatives and with succinic anhydride to give the 5, 6-bis-(arylimino)-4,7-dioxodecanedioic acid, respectively.read more
G H SAYED ,M S. ABD ELHALIM ,M A SAYED ,A Y EL-KADY ,L M. ABD ELWAHAB ,
- 29 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 53
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Preparation, physical properties and nuclear magnetic resonance spectral (1H and 13C) data of 2-[2-hydroxypropyl]- and 2-[3-hydroxypropyl]-benzimidazoles (1) and (2) have been described.read more
MASHOODA HASAN ,MARIA C.GARCIA ALVAREZ ,FARZANA LATIF ,
- 29 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 57
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Preparation, physical properties, mass and proton magnetic resonance spectral data of 2-alkyl (CH3/C2H5)-5-nitro-benzimidazoles (1) and (2) and their p-toluene sulfonyl derivatives (3) and (4) have been described. Two benzimidazoles (5) and (6) having same alkyl substituents but no nitro group in 5-position and their p-toluene sulfonyl derivatives (7) and (8) were prepared and studied for the sake of comparison of their n.m.r spectral properties with (3) and (4). In addition (1) and (2) were reduced to 5-amino-benzimidazoles (9) and (10)read more
MARIA C.GARCIA ALVAREZ ,NAGHMANA RASHID ,FARNAZ MALIK ,MASHOODA HASAN ,
- 29 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 65
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A possible method for the determination of amino acid sequence of polypetides involves their degradation into dipeptide fragements with dipeptidyl amino peptidase I (Cathepsin C). The action of the enzyme was characterized on different model paptides of known structure. Some tryptic paptides of rabbit muscle aldolase were isolated by gel filtration on Sephadex G-25 column and purified by electrophoretic and chromatographic methods. These peptides and synthetic peptide ACTH1-32 were subjected to dipeptidyl aminopeptidase I digestion. The yield of the dipeptides were reasonable good and the structure of the dipeptides was determined by dansyl Edman method, thin layer ion exchange chromatography and high voltage electrophoresis. The action of dipeptidyl aminopeptidase I (Cathepsin C) was completely inhibited by internal prolyl residues. read more
MASOOD R BAIG ,IKRAM ULLAH KHAN ,AHMAD SAEED ,
- 30 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 79
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not availableread more
A A EL-EMAN ,M M EL-KERDAWY ,M A MOUSTAFA ,
- 30 Jun 2011
- Volume Detail: VOLUME 9, NO1, MAR 1987
- Pages: 87
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